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2 edition of effect of ovariectomy on bone changes in the mandible of adult female rats. found in the catalog.

effect of ovariectomy on bone changes in the mandible of adult female rats.

Emad Saleh Elsubeihi

effect of ovariectomy on bone changes in the mandible of adult female rats.

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Published .
Written in English


Edition Notes

Thesis (Ph.D.) -- University of Toronto, 2003.

The Physical Object
Pagination141 leaves.
Number of Pages141
ID Numbers
Open LibraryOL19734728M
ISBN 100612780341

shown the influence of an ovariectomy (OVX) on the skeleton in animals and the effect of intervention on the skeleton in OVX animals. It has been suggested that OVX nonhuman primates are a good model for postmenopausal osteoporosis because their trabecular and . GONADOTROPIN LEVELS IN LACTATING RATS; EFFECTS OF OVARIECTOMY. Iowa State University, Ph.D., I Physiology! University Microfilms, A XEROK Company, Ann Arbor, Michigan THIS DISSERTATION HAS BEEN MICROFILMED EXACTLY AS RECEIVED. An ovariectomized rat (OVX) is a female rat whose ovaries have been removed. Currently there is no single animal model that identically represents the stages of osteoporosis in humans although there are some animals that are relatively close and can be used for the purpose of comparison. Both small animals and large animals are used depending on which aspects of the osteoporotic condition are. Ovariectomy: Place animal in sternal recumbency. Make a midline incision, approximately 1cm in length, in the middorsum of the - animal. The skin is gently separated from the underlying muscleusing cotton swabs or a blunt probe. Locateeach ovary by visualizing a white spot under the muscleon the flanks of the Size: KB.

This study was designed to evaluate bone quality in the posterior maxilla of ovariectomized rats in order to validate this site as an appropriate model to study the effect of osteoporotic changes. Methods: Forty-eight 3-month-old female Sprague-Dawley rats were randomly divided into two groups: an ovariectomized group (OVX, n=24) and Sham Cited by:


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effect of ovariectomy on bone changes in the mandible of adult female rats. by Emad Saleh Elsubeihi Download PDF EPUB FB2

In order to quantify the rate of bone metabolism after ovariectomy, tetracycline was injected intraperitoneally into 3-month-old female Wistar rats to label the mineralizing effect of ovariectomy on bone changes in the mandible of adult female rats.

book and ovariectomy was performed. The rats were sacrificed 91 days later, whereupon serum Cited by: Similarly, Hara et al. 5 showed that an ovariectomy duration of weeks had no effect on cortical bone loss in the mandible, using a rat animal model.

Jiang et al. 6 concluded that ovariectomy did not affect cortical bone loss in the mandible compared to sham-operated animals, Cited by:   To unveil the relationship between changes in BMD and bone marrow haematopoiesis in adult animals suffering from osteoporosis, we chose 3-month-old rats as experimental models.

Several previous studies showed that in rats, oestrogen levels decreased precipitously accompanied by bone mass loss following by: Animals. A total of 63 (n = 27 for Experiment1, n = 36 for Experiment 2) weanling female Sprague-Dawley rats were obtained from Harlan (Madison, Wisconsin).These rats were part of a larger experiment examining changes in binge eating patterns from pre-puberty into adulthood (Klump et al., submitted).Cited by:   Therapeutic effect of localized vibration on alveolar bone of osteoporotic rats.

Methods and materials Adult female Sprague-Dawley rats were divided into five groups: 1). Objective This study used microcomputed tomography (micro-CT) to evaluate the effects of ovariectomy on the trabecular bone microarchitecture and cortical bone morphology in the femoral neck and mandible of female rats.

Materials and Methods Twelve female Wister rats were divided into two groups: the control and ovariectomized groups. The rats in the ovariectomized group received ovariectomy. To investigate the effects of ovariectomy (OVX) on rat mandibular bone, the physicochemical compositions of mandibular cortical bone of ovariectomy and sham operated rats 2.

In the ovx rats, aging led to a 20% and 7% decrease in stiffness and bone area fraction of the mandibles in the old rats compared with that in the adult rats.

In the adult ovx rats, the increase in structural properties of the mandible may be a consequence of an increase in masticatory function as it has been reported that ovx rats eat Cited by: Ovariectomy induced high bone turnover in rats, where serum ALP level was increased Effects of Ovariectomy on Biochemical Markers Three studies (Table 1) [5,7,8] revealed that ovariectomy causes marked biochemical changes as decreased serum calcium (CA) and phosphorus (P) level together with increased serum alkaline phosphatase (ALP) Size: KB.

The long-term skeletal effects of ovariectomy and aging were studied in female Sprague-Dawley rats sacrificed at, and days after bilateral ovariectomy (OVX) or sham surgery at 90 days of age.

The proximal tibia was processed undecalcified for quantitative bone histomorphometry. For continuity, data from these late time points were combined with previously published data from Cited by: This study aimed at investigating the effect of ovariectomy onto the stimulation of intracortical remodeling in rat mandibles.

Materials and Methods. Sixteen week-old Spraque-Dawly (SD) female rats were randomly assigned into two groups, receiving either ovariectomy or sham operation. All the rats were sacrificed 18 weeks by: 7.

comparism to those in control rats, while progesterone is lower between 4 and 20 hours after ULO. De Jong et al () observed minor changes in circulating estradial level after bilateral ovariectomy (BLO) on the days of proestrus and metestrus.

Battey and Romeo () evolved ovariectomy as a remedy of otherwise incurable ovarian diseases. mandible and teeth and the level of alkaline and acid phosphatases in ovariectomized rats with or without 17β-estradiol supplementation.

Material and Methods Young, adult female Wistar rats, weighing g were used. The animals were fed a standard chow and housed in the cages with light-dark cycle and allowed free access to water and diet. To clarify the changes of the mandible and alveolar bone in postmenopausal osteoporosis, we examined the changes of structure in mandible and alveolar bone of ovariectomized (OVX) rats.

Twelve female Wistar rats (week old) were divided into two groups equally. Nine weeks after ovariectomy, we examined the mandibles of OVX and sham control.

Lasota A, Danowska-Klonowska D. Experimental osteoporosis - different methods of ovariectomy in female white rats. Rocz Akad Med Bialymst ;49(Suppl 1): [ Links ] 5. Park SB, Lee YJ, Chung CK. Bone mineral density changes after ovariectomy in rats as an osteopenic model: stepwise description of double dorso-lateral approach.

Ovariectomy, therefore, produced no significant changes in the hard palate, but affected bone dynamics in the mandible and tibia. However, dietary calcium deficiency induced bone loss and increased bone turnover in the hard palate, mandible and proximal tibia, independently of by: EFFECTS OF OVARIECTOMY, SEASONAL CHANGES, AND ANATOMICAL POSITION ON THE COMPACT BONE REMODELING AS SEEN IN THE ADULT OVINE MODEL Erica Wong The purpose of this study is to characterize the compact bone remodeling of the ovariectomized ewe and its effectiveness as an animal model for studies of postmenopausal osteoporosis.

easier, less time consuming and less harmful for the used female white rats. Key words: model of osteoporosis, ovariectomy, female rats. Introduction Osteoporosis is a chronic, systemic, metabolic disease of the skeleton, characterised by reduced bone mass, architectural defects and lowered mechanical resistance to injuries, what.

The shaded areas correspond to physiological 17β-estradiol serum concentrations in intact female rats and mice respectively. increases brain lesions in the cortex and lateral striatum after transient occlusion of the middle cerebral artery in rats: no effect of ischemia on "Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Cited by:   It has been suggested that fruit and vegetable consumption are associated with good bone health.

Onion, in particular, has been verified in its efficacy in bone resorption activity. In this study, we further investigated the effects of an onion-containing diet on ovariectomy-induced bone loss using methods of serum marker assay, histomorphometric analysis and biomechanical tests.

Sixty-four. mandible. Only a decrease in bone area fraction was observed (4). In other experimental studies carried out on rats after ovariectomy, it was showed that only extraction of molar tooth in the mandible and only ovariectomy did not cause changes in stiffness of the mandible.

But when these two factors occurred together, stiffness of. Discussion The present study demonstrated that masticatory hypofunction is the major factor to induced mandible bone loss and cause deleterious effect on bone quality of in female Wistar rats.

Ovariectomy in rats is known to cause bone loss in vertebra and in femur (Wronski, ). During growth and in the young adult period, there is a positive bone balance, i.e., more bone is formed than is absorbed. Fifty-six female 7-week-old Wistar rats (Rattus norvegicus albinus) with initial body mass of Whole-body vibration improves fracture healing and bone quality in rats ith ovariectomy-induced osteoporosis Acta.

Since changes in alveolar bone structure [38, 39] and density have been reported by ~9 weeks after ovariectomy, it is possible that DXA may not be sensitive enough to detect the ovariectomy-induced changes in the rat mandible.

Studies that follow for a longer time period after ovariectomy are likely needed to detect ovariectomy-induced loss of Cited by: With ethical approval, a total of 64 virgin female Wistar rats were used in this study.

There were two age groups, 12 weeks and 24 weeks (n=32). Half of the rats in each age group (n=16) received bilateral ovariectomy (OVX) and the other half received sham operation (Sham).File Size: KB. OVF models using various animal species should be developed to evaluate the therapeutic strategy in preclinical testing.

We developed an OVF model in rats. Rat osteoporosis was induced by ovariectomy (OVX), and 3 months after OVX, a 3 mm diameter hemispheric vertebral bone defect was developed in lumbar vertebra 6 (L6).Author: Geng-Yang Shen, Hui Ren, Jing-Jing Tang, Ting Qiu, Zhi-Da Zhang, Wen-Hua Zhao, Xiang Yu, Jin-Jing Hu.

the adult rat skeleton: mature from months of age and aged months of age. Skeletal growth is rapid from months, reduced from months, and negligible past months of age [ ]. In addition to continued longitudinal bone growth, the extent of ovariectomy-induced bone loss.

the effects of ovariectomy (OVX) and naproxen treatment on both femoral and mandibular bone mass and biomechanical competence. MATERIAL AND METHOD Sixty female Sprague-Dawley rats of 24 weeks old * Department of Physiology, Faculty of Dentistry, Istanbul University, Istanbul, by: 1.

the Lordosis Response of Female Rats JUDITH K. MOREINES AND J. BRADLEY POWERS: Department of Psychology and Neuroscience Laboratory, University of Michigan, Ann Arbor, MI (Received 27 November ) MOREINES, J. AND J. POWERS. Effects of acute ovariectomy on the lordosis response female rats.

PHYSIOL. BEHAV. growing estrogen-deficient rats show abnormalities in bone formation, affecting both the length and density of the bone, and indicating that estrogen is necessary for normal bone development.

Ovariectomized (ovx) adult rats effectively model the estrogen deficiency seen in post-menopausal women and its skeletal effects.

also demonstrated that Ge had a beneficial effect on femoral bone mass in OVX rats. Our recent study (25) of OVX rats fed a low-calcium diet showed that bone loss occurred in the mandible accompanied by systemic osteoporosis.

However, the effects of the above agents on mandibular bone loss in OVX rats remain uncertain. EFFECTS OF OVARIECTOMY AND ANATOMICAL LOCATION ON OSTEONAL ENCROACHMENT IN ADULT CORTICAL OVINE BONE A Thesis Presented to the Faculty of California Polytechnic State University, San Luis Obispo In Partial Fulfillment of the Requirements for the Degree Master of Science in Biomedical Engineering By Paige Ryan February To investigate the effects of ovariectomy (OVX) on rat mandibular bone, the physicochemical compositions of mandibular cortical bone of ovariectomy and sham operated rats 2, 4, and 8 months after surgery were compared using Raman by: 7.

alkaline phosphatase [13] and the bone-specific bone gla-protein [BGP] [3]). The purpose of this study was to investigate which changes of these bone markers occur in rats after ovariectomy. Moreover is was of interest to compare the biochemically measured parame- ters of bone turnover with histomorphometrical bone parameters.

The most. Effect of Ovariectomy on Stimulating Intracortical Remodeling in Rats F: OVX changes the microarchitecture in rat mandibles. Micro-CT images show remarkable trabecular bone loss in OVX rats (a) compared with that in the control (b) group.

Photomicrograph of mandible in OVX rats viewed with uorescent light. Labeled osteons (indicated by. Alfacalcidol treatment increases bone mass from anticatabolic and anabolic effects on cancellous and cortical bone in intact female rats.

J Bone Miner Metab ;– Crossref, Medline, Google Scholar; 16 Lelovas PP, Xanthos TT, Thoma SE, Lyritis GP, Dontas IA. The laboratory rat as an animal model for osteoporosis by: can also prevent bone loss and reductions in bone strength in ovariectomized rats [10, 11].

Taken together these data suggest that total-body vibration might differentially affect bone cell activities, thus leading to enhanced bone mass or reduced bone loss associated with estrogen deficiency. However, it remains to be determined whether estrogensCited by:   Bilateral ovariectomy or adrenalectomy are experimental tools used to understand the mechanisms regulating the hypothalamus-pituitary-ovarian and the hypothalamus-pituitary-adrenal axis.

There is evidence that acute unilateral perforation of the dorsal peritoneum in rats results in significant changes in progesterone, testosterone and estradiol serum by: Changes in Biochemical Measurements due to Electrical Stimulation of Ovariectomized Rat Bones adult female wistar rats (90 days old and gm body wt.) were obtained from animal facility of Jawaharlal Effect of ovariectomy and pulsed electric field treatment on.

tions and micro-CT of the mandible and tibia for all parameters. The mandible could be used as an alterna-tive site with which to evaluate the bone morphometry of metabolic bone diseases Strengths and limitations This is the first study, using rodent models, to compare bone micro-architectural analysis of bone disease between undecalcifiedFile Size: 2MB.

Shoji K, Elsubeihi E, Heersche JNM.“Effects of ovariectomy on turnover of alveolar bone in the healed extraction socket in rat edentulous mandible”. Arch Oral Biol. (2); Elsubeihi E.S. and Heersche J.N.M. “Comparison of the effect of ovariectomy on bone mass in dentate and edentulous mandibles of adult rats”.Experimental osteoporosis was studied in mandible bone by means of ovariectomy and vitamin D insufficiency.

METHODS: 42 female Wistar rats were divided into the following four groups: (1) ovariectomized rats maintained in 12h day-night light conditions (ov-l), (2) ovariectomized rats maintained in 24h dark light conditions (ov-ob), (3) sham. Abstract Objective: The main objective of the study was to explore the effect of Activator manipulation in OVX rats.

Methods: Animals The protocol, using a limited number of female Sprague-Dawley rats (6 months of age) (Charles Rivers International, Barcelona, Spain) undergoing either shamoperation (Sh) (n=10) or ovariectomy (OVX) (n=15), was approved by the Institutional Animal [ ].